Importantly, HSPG/MMP levels and Wg signaling are altered in parallel in dfmr1 null animals, and the genetic reduction of Dlp, or genetic/pharmacological reduction of secreted MMP1, both correct Drosophila FXS disease model phenotypes (Siller and Broadie, 2011; Friedman et al., 2013). The gene discussed is TXNL4B; the disease is fragile X syndrome.