BDNF and Huntington disease: Both BDNF (Zuccato et al., 2008), and CREB (Obrietan and Hoyt, 2004; Choi et al., 2017) have been directly implicated in HD pathology, while CREB is also believed to play a critical role in dopamine receptor-mediated nuclear signaling (Andersson et al., 2001), and disruption of the protein's function leads to neurodegeneration (Mantamadiotis et al., 2002; Devi and Ohno, 2014).