For example, in the colon, TREM-2 has been reported to be important in wound-healing.15 In the brain, TREM-2 functions to clear apoptotic neurons and limit microglial proinflammatory responses.11 16 Our work suggests that TREM-2 could be an attractive target for promoting the resolution of inflammation during liver injury and for the prevention of parenchymal cell death, this akin to events described for TREM-2 in neuroinflammatory diseases and sepsis.16 49. The gene discussed is TREM2; the disease is Sepsis.