LIPA and lysosomal acid lipase deficiency: Lysosomal Acid Lipase Deficiency (LAL-D) is an autosomal recessive disease caused by pathogenic variants of the LIPA gene leading to absent or decreased activity of LAL enzyme, which results in a progressive lysosomal accumulation of cholesteryl esters (CE) in hepatocytes, adrenal glands, intestines and macrophage-monocyte cells [1].