Diseases secondary to LAL-D are a continuum, classically divided into the complete LAL deficiency, causing infantile-onset LAL-D (formerly known as Wolman Disease, WD), and the LAL deficiency with residual enzymatic activity leading to a childhood/adult-onset form (formerly known as Cholesteryl Ester Storage Disease, CESD). The gene discussed is LIPA; the disease is cholesteryl ester storage disease.