None of the patients was followed by liver biopsy and we cannot exclude spontaneous improvement in ALT as liver cirrhosis is found in histology, but no progression of liver disease is demonstrated in our three patients, who only have a mild fibrosis after 9 years (patient 1 and patient 2) and 10 years (patient 3) of treatment on Fibroscan elastography. The gene discussed is GPT; the disease is liver disorder.