After 9 years of treatment in Patients 1 and 2, and 10 years of treatment in Patient 3, all three subjects showed reduction of ALT, TC and TG (Table 2, Fig. 2) and mild liver fibrosis by hepatic elastography with Fibroscan: Patient 1 stiffness 7.0 kPa; Patient 2 stiffness 7.9 kPa; Patient 3 stiffness 7.0 kPa. This evidence concerns the gene GPT and Hepatic fibrosis.