GenIO was also successfully validated with different well known cases such as Miller syndrome in Ng et al., 2010 [22], Nature Genetics (causative gene: DHODH), and with Schinzel-Giedion syndrome in Hoischen et al., 2010 [23], Nature Genetics (causative gene: SETBP1), both included as examples in the GenIO web server. This evidence concerns the gene SETBP1 and postaxial acrofacial dysostosis.