KDM1A and neoplasm: During tumor formation, aberrant DNA methylation facilitate acquisition of the malignant phenotype, such as demonstrated in PDAC, where DNA methylation is an established tumor suppressor -inactivating mechanism26.Our findings in Fig. 5 is also consistent with those of Qin et al. 27, where the genetic silencing of LSD1 repressed the PDAC cell proliferation and tumorigenicity, as well as is therapeutically-relevant especially as LSD1 has been shown to be significantly upregulated in PDAC patient samples, and positively correlated with the overall survival of PDAC patients.