Since the hallmark of EMT is the loss of epithelial surface marker expression, most notably E-cadherin, and the gain of mesenchymal markers such as vimentin and N-cadherin, we believe our finding highlights the efficacy of the hydroxamic acids in targeting the critical HDAC-mediated tumorigenesis and tumor progression by deregulating PDAC-relevant signaling bio-events such as the EMT, known to be associated with the CSCs phenotypes, including resistance to therapy and metastasis22,23. This evidence concerns the gene CDH2 and neoplasm.