SOX2 and familial pancreatic carcinoma: Since the presence of CSCs have been demonstrated in pancreatic cancer and implicated in the aggressive phenotype of PDAC cells12–14, we evaluated if SAHA or TSA exhibits any inhibitory effect on the CSCs- like phenotype of PDAC cells and their associated aggressiveness, by examining the effect of 1 M SAHA or TSA treatment on the mRNA expression of CSC transcription factors - Oct-4, Sox-2 and Nanog in the PANC-1 or MiaPaca-2 at the 24 h and 48 h time points.