FH and age-related macular degeneration: Individuals homozygous for the Y402H polymorphism in CFH have been found to have higher levels of CRP in the choroid at the back of the eye26, and interestingly the AMD-associated 402H form of FH has been shown to have reduced binding to mCRP20 and is less able to inhibit the inflammatory effects of mCRP in RPE cells27.