Quantitation of staining revealed a trend towards higher PTX3 levels in AMD eyes and hinted at a possible relationship with AMD-associated SNPs, i.e. those responsible for the deletion of factor H related genes 1 and 3 (CFHR1-3) and the Y402H coding change (Figs 5 and S5); however, additional analysis with a greater number of donor samples would be required to investigate this further. Here, PTX3 is linked to age-related macular degeneration.