Given the likelihood that FHL-1 plays a more significant role in complement regulation than previously thought, particularly in the human eye5, we have compared the binding of FH and FHL-1 to both CRP and PTX3, investigated the effect of the AMD-associated Y402H polymorphism on these interactions, and investigated whether the FHL-1 tail contributes to binding. Here, CRP is linked to age-related macular degeneration.