HTRA1 and age-related macular degeneration: Given the trend towards increasing PTX3 with AMD we stratified our samples for another high-risk genotype for AMD (SNPs in Chromosome 10 (Chr-10) around the ARMS2/HTRA1 genes) as well as a common AMD-protective genotype that includes the deletion of the CFHR1 and CFHR3 genes (Figs 5B–D and S5B–D).