We stained paraffin sections from colon cancer biopsies of three individuals with antibodies against Aconitase 2 as a reporter of mitochondrial mass and, simultaneously, against one of the proteins Bax, Bcl-2, Bid, Mcl-1, Smac, XIAP, Casp8 and Bar (Fig. 7a). Here, CASP8 is linked to malignant colon neoplasm.