Notably, the EHMT2 inhibitor UNC0638 was extremely effective in inhibiting cell growth in both PC9/ER and HCC827/ER cells but showed a relatively weak inhibition in their parental cells (see Supplementary Fig. 1A), suggesting that EHMT2 plays an important role in EGFR-TKI resistance in NSCLC cells. Here, EHMT2 is linked to non-small cell lung carcinoma.