As shown in Fig. 4b, treatment with UNC0638 and EHMT2 siRNA resulted in significant upregulation of PTEN mRNA expression levels (2.5–5 folds) in the corresponding groups compared to the control groups (DMSO and Scramble groups), suggesting that EHMT2 regulates PTEN expression at the transcriptional level in EGFR-TKI-resistant NSCLC cells. This evidence concerns the gene PTEN and non-small cell lung carcinoma.