Notably, SNP-bearing LMRs were strongly associated with genes, which have previously been identified in genetic forms of cardiac channelopathies, including pacemaker channels (HCN4—Brugada syndrome), multiple K+ channels (KCNE1, KCNH2, KCNJ2, KCNQ1—long and short QT syndromes), and voltage-gated Na+ channels (SCN5A—Brugada syndrome, sick sinus syndrome)53. The gene discussed is HCN4; the disease is sick sinus syndrome.