Then, we stained the tumor sections for ANXA3 and Ki67 utilizing IHC staining and showed that ANXA3 was indeed downregulated in the ANXA3-knockdown group, and that ANXA3 knockdown was correlated with much higher Ki67 expression, which characterizes cell proliferation activity (Fig. 3c, d). The gene discussed is ANXA3; the disease is neoplasm.