p63 expression was lost in the p53 mutant HPV-negative cervical carcinoma cell line C33A, was undetectable in SiHa cells, which contain only 1–2 copies of integrated HPV-16 DNA and was very high in CaSki cells, which contain around 600 copies of integrated HPV-16 DNA. The gene discussed is TP53; the disease is cervical carcinoma.