Reversal of heart failure is rare, reported in a case of presumed juvenile hemochromatosis but without confirmatory genetic analysis [16], associated with a mutation in the HAMP gene [17] and most recently in association with a HJV mutation [18] like in our case but in all with less advanced heart failure with LV ejection fraction > 20% as compared to 5–10% requiring emergent mechanical circulatory support as in this case. Here, HAMP is linked to heart failure.