Prior studies have shown a weak non-significant correlation between platelet count measured as a continuous variable and CRP in both stable [8] and exacerbated [10] COPD, however, in this study thrombocytosis was associated with significantly elevated CRP, as participants with thrombocytosis had significantly higher median CRP (4.6 vs. 3.0, p = 0.01), implying that systemic inflammation may play a role in the pathway between platelet elevation and COPD morbidity. This evidence concerns the gene CRP and thrombocytosis disease.