Although initial evidence, based on the results of immunohistochemical analysis of skin biopsies from AD patients, argued against a critical role of Gal-3 in the binding of monoclonal or serum Ig-E [89], many experimental results obtained using mouse models of AD suggest that Gal-3 plays a critical role in the development of the allergic inflammatory response in AD [90]. This evidence concerns the gene IGHE and Alzheimer disease.