Many efforts have been made recently to find biomarkers that might help in the risk stratification, and prognostication of acute and chronic heart failure beside the well-established markers, such as the brain natriuretic peptide (BNP) and its N-terminal part (NT-proBNP), the soluble suppression of tumorigenicity 2 (ST2), the growth differentiation factor-15, and the highly sensitive troponins. Here, NPPB is linked to congestive heart failure.