Gal-3 levels in plasma were, in fact, found to be positively associated with known cardiovascular risk factors, as age, sex, diabetes, hypertension, hypercholesterolemia, body mass index, renal function and smoking and was proposed as an additional prognostic factors, useful to identify high-risk patients in whom additional care management efforts and advanced therapies could be warranted. The gene discussed is LGALS3; the disease is diabetes mellitus.