In a pivotal paper published in 2004 by Sharma and colleagues [92] Gal-3 was identified as the most upregulated protein in an animal model of left ventricular hypertrophy (LVH) and HF suggesting that Gal-3 is a critical player in the pathogenesis and progression of HF. The gene discussed is LGALS3; the disease is left ventricular hypertrophy.