In agreement with human studies, also in mice models in which hyperglycemia was induced after high-fat diet feeding with a corresponding threefold increase in homeostasis model assessment for insulin resistance (HOMA-IR) index and a 1.5-fold decrease in Akt activation, indicate that Gal-3 expression was increased in endothelial cells as well as in blood, suggesting that Gal-3 plays a role in the vascular response in DM [204]. This evidence concerns the gene LGALS3 and Insulin resistance.