Meanwhile, TP could significantly reduce the expression of RANKL and RANK, enhance the level of osteoprotegerin (OPG) in joints and sera of CIA rats, as well as decrease RANKL and RANK level and increase OPG production in the coculture system of human FLSs and peripheral blood mononuclear cells (PBMCs), which further revealed that TP might attenuate RA in part by preventing bone destruction, and inhibit osteoclast formation by regulating the RANKL–RANK–OPG signaling pathway [54]. The gene discussed is TNFRSF11A; the disease is rheumatoid arthritis.