Taken together, these results demonstrated that the SYK gene was successfully expressed in DCs by lentivirus infection and that SYK-DCs generated in vitro could stimulate naïve T cells to become active and express higher levels of CD3+CD8+, TCRαβ+, CD3+CD38+, and CD3+HLA-DR+ compared with controls. This evidence concerns the gene CD38 and lentivirus infection.