Consistently across different models, mitochondrial dysfunction was observed for autosomal recessively inherited forms of PD caused by mutations in the genes coding for PINK1, Parkin and DJ-1 proteins (Valente et al. 2004; Lücking et al. 2000; Bonifati et al. 2003) (Fig. 1). The gene discussed is PARK7; the disease is Parkinson disease.