SYNJ1 and Parkinson disease: Indeed there is increasing evidence of monogenic causes of PD (PARK19, PARK20 or PARK21) that are directly involved in the shuttling of vesicles and maturation into lysosomes for degradation of not only mitochondria but also other organelles and protein aggregates (Edvardson et al. 2012; Köroĝlu et al. 2013; Krebs et al. 2013; Quadri et al. 2013; Vilariño-Güell et al. 2014).