Mutations and polymorphisms in the fibrinogen gene, C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, C1565T mutation in the platelet glycoprotein IIIa (GPIIIa) gene, and factor VII gene and others should be analyzed to determine the contribution of inherited thrombophilic mutations to thrombotic complications in patients with SCD. This evidence concerns the gene ITGB3 and Schnyder corneal dystrophy.