In the present research, some pathological biomarkers of the two subtypes of breast cancer, such as microvessel density (MVD), matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF-1)expression levels, were evaluated to explore the pathological basis of quantitative DCE-MRI and ADC value. This evidence concerns the gene MMP2 and breast cancer.