SIRT6 and type 2 diabetes mellitus: The relationship between Sirt6 and diabetes is complex, although Sociali G. reported that pharmacological Sirt6 inhibition improved glucose tolerance as well as reduced triglycerides and cholesterol levels in a T2DM mouse model [31]; most models have confirmed the hypothesis that Sirt6 serves as a surrogate diagnostic and therapeutic marker of DM with or without cardiovascular complications.