Interestingly, the expression of Sirt6 mRNA, but not protein, in the EMPs from DM patients and high glucose-incubated HUVECs is consistently decreased; additionally, Sirt6 mRNA and protein deficiency has also been confirmed in HUVECs following high glucose treatment in our study, suggesting that Sirt6 might have significant effects on the pathogenesis of diabetic complications. The gene discussed is SIRT6; the disease is diabetes mellitus.