INS and Hyperglycemia: In terms of glucose metabolism, the synthetic agonists of PPARγ, thiazolidinediones, have been shown to improve glucose tolerance by enhancing insulin sensitivity and restoring the function of β-cells in diabetic subjects [29], and patients with a dominant-negative mutation in the PPARγ genes showed severe hyperglycemia, suggesting the important role of PPARγ in regulating glucose homeostasis [13].