On the other hand, study investigating the mRNA expression of PPARγ in leukocyte showed that PPARγ was up-regulated in patients with GDM and positively correlated with glucose concentrations at 1 h and 2 h of 75 g oral glucose tolerance test (OGTT) and also negatively correlated with plasma high density lipoprotein (HDL) cholesterol concentration [17]. The gene discussed is PPARG; the disease is gestational diabetes.