Similar to their researches, in our study, we investigated MMP-2、MMP-9 expression in A375 and MeWo cells respectively, our results revealed that LKB1 knockdown cooperating with BRAF mutation in melanoma may cause the activation of PI3K/Akt/mTOR signaling pathway, then promote to the secretion of MMP-2, while there had little effect on MMP-9 expression (Data not list). The gene discussed is MMP9; the disease is melanoma.