In human bladder cancer, miR-489 targets mRNA of JAG1, a Notch ligand, to suppress the proliferation and invasion of tumor cells [24]; In lung cancer cells, inhibition of miR-489 upregulates the expression of N-cadherin and vimentin but decrease the level of E-cadherin to promote the epithelial mesenchymal transition (EMT) [25]. This evidence concerns the gene CDH2 and urinary bladder cancer.