On multivariate analysis, factors associated with poor prognosis were tumor number (HR: 1.90; p <0.001), tumor size (HR: 1.45; p = 0.02), CEA (HR: 1.69; p <0.001), GGT (HR: 1.47; p = 0.01) and adjunctive therapy (HR: 0.65; p = 0.001). The gene discussed is CEACAM5; the disease is neoplasm.