MGMT and central nervous system cancer: In comparison of BICD1 with MGMT expression in predicting the overall survival of glioma patients by the Kaplan-Meier survival analysis, high BICD1 expression showed more significant impact (P<0.000001) than high MGMT expression (P=0.00003) on worse overall survival in the TCGA GBMLGG cohort (Figure 4A).