Furthermore, TUG1 has been reported to trap miR-145 and downregulate its expression in several tumor types, stimulating cell proliferation and invasion in gastric cancer [27], promoting self-renewal in glioma stem cells by upregulation of SOX2 and c-Myc expression [9], and facilitating bladder cancer cell invasion by stimulating ZEB2-mediated EMT [30]. This evidence concerns the gene SOX2 and central nervous system cancer.