The TCGA data also showed that p57 exhibited a lower expression in tumor than in adjacent normal tissue in urothelial bladder cancer, breast cancer, colon and rectal adenocarcinoma, chromophobe renal cell carcinoma, ccRCC, lung adenocarcinoma etc. In addition, we also found that knockdown of Lucat1 increased the expression of p57 in ccRCC cells. This evidence concerns the gene CDKN1C and breast cancer.