As for PRC2 complex exerts its epigenetic functions in the nucleus, we first investigated the subcellular localization of Lucat1 in ccRCC and found that a considerable increase in Lucat1 expression in the nucleus versus the cytosol (Figure 3A, 3B, 3C), suggesting that Lucat1 may have a major regulatory function at the transcriptional level through PRC2. The gene discussed is LUCAT1; the disease is nonpapillary renal cell carcinoma.