For instance, Yoon et al. [7] demonstrated that in breast cancer cells PTTG1 promotes epithelial to mesenchymal transition (EMT) and expansion of the cancer stem cell population via AKT activation, while Zhang et al. [17] reported that PTTG1 enhanced breast cancer cell proliferation through inhibition of TGF-β signaling. The gene discussed is TGFB1; the disease is breast carcinoma.