To assess whether PTTG1 silencing affected melanoma cell sensitivity to the growth suppressive effect of dabrafenib, A375, A375R, SK-Mel28 and SK-Mel28R cells were transfected with either siPTTG1 (hereafter referred to as siPTTG1/cells) or siCTRL (hereafter referred to as siCTRL/cells), and 24 h later incubated with graded concentrations of the drug. This evidence concerns the gene PTTG1 and melanoma.