BEND5 and colorectal carcinoma: Using this array, we analyzed 26 paired CRC and noncancerous colorectal tissues and found multiple hypermethylated loci in the promoter and exon 1 regions of BEND5. The coding sequence of BEND5 is located on chromosome 1p33 and comprises 1266 nucleotides that encode a predicted protein of 421 amino acids [17].