In the present study we performed lipotoxicity analysis in AML-12 cells exposed to palmitate (0.25mM), one hour pre-incubated with SCD-1 inhibitor (MF-438, Calbiochem) where we found enhanced lipotoxicity (40-42% cell death) as compared to cells exposed to palmitate only (20-21% cell death) (Supplementary Figure 1C). The gene discussed is SCD; the disease is acute myeloid leukemia.