Among these, the best known is the NLR (nucleotide-binding domain leucine-rich repeat-containing receptor) pyrin domain-containing protein 3 (NLRP3) inflammasome, a crucial factor of innate immunity with a role in many diseases, including microbial infections, rheumatic diseases, diabetes, and atherosclerosis [3, 4]. Here, NLRP3 is linked to diabetes mellitus.