Of note, here we identified MSH2 c.815C > T together with another VUS (DVL2 c.596 T > C) and a path_BRCA2 c.9382C > T (different from the familial path_BRCA2) in a patient diagnosed with ductal carcinoma at 44 years of age (Patient 1,100,948) (Table 1). Here, DVL2 is linked to breast ductal adenocarcinoma.