In addition, we found a number of VUS in genes other than BRCA1/2 i.e. AXIN2, APC, DVL2, MAP3K1, RAD51B, NBN, POLE, CDH1, CDX2, MRE11A, MUTYH, NOTCH3, PTEN and RAD51D. All these may be suspected of being associated with cancer in the families studied and may be considered as candidates for being included in future gene panel testing to better understand why some families present aggregation of cancer cases. This evidence concerns the gene POLE and cancer.