Levels of markers regulated by histone acetylation such as PTEN, MARCKs, EGFL-7 (almost significant decrease), FGFRL-1, SNAIL-1, P63, and k-RAS were significantly reduced in the lung tumors compared to non-tumors only in patients with LC-COPD. Here, PTEN is linked to laryngotracheoesophageal cleft.