Tumor expression levels of miR-126 did not significantly differ between LC-COPD and LC patients, whereas in the former patients, an almost significant decrease in EGFL-7 expression was observed (p = 0.073, Fig. 1c and Table 2), together with a decrease in TOM-1 and CRK expression and a rise in angiopoietin-2 content (Table 2). Here, ANGPT2 is linked to chronic obstructive pulmonary disease.