SPRY2 and chronic obstructive pulmonary disease: Furthermore, expression levels of the downstream markers of the corresponding microRNAs, namely PTEN, MARCKs, TPM-1, PDCD4, SPRY-2, ETS-1, ZEB-2, FGFRL-1, EFNA-3, and k-RAS were downregulated in the lung tumor lesions of patients with the underlying condition compared to non-COPD patients (Table 4).