Furthermore, non-tumor lung expression levels of miR-210 and miR30a-30p and their downstream markers FGFRL-1, EFNA-3, P62, LC3II/LC3I, beclin-1, BAX, BCL-2, SNAIL-1, P53, CDKN1A, and ki-67 did not significantly differ between LC-COPD and LC patients (Fig. 2a, b, Additional file 1: Figures S2, S3 and Table 2). This evidence concerns the gene EFNA3 and chronic obstructive pulmonary disease.