The MM lesion carried a <i>BRAF</i><sup>V600E</sup> and a <i>TERT</i> promoter mutation.As the family story was consistent with a genetic predisposition to cancer, we performed mutational analysis of genes involved in familial melanoma and CLL, and of <i>BRCA1</i> and <i>BRCA2</i>. The gene discussed is BRAF; the disease is B-cell chronic lymphocytic leukemia.