Typical high-grade genomic biomarkers featured the CLL: the immunoglobulin heavy variable genes were unmutated; a clonal del(11q), involving <i>ATM</i> and <i>BIRC3</i>, was present in the peripheral blood (PB) and skin lesion, while a subclonal large del(13q)/D13S319<i>-RB1</i> was detected only in the PB. Here, BIRC3 is linked to B-cell chronic lymphocytic leukemia.