In less advanced cancers with stage I and II the overrepresented region gain 1 contained at least 2 genes of interest: overexpressed TREM2 gene known to be implicated in cell proliferation, was observed in early cases of esophageal cancer [39, 40] whereas the TFEB gene, a transcription factor for lysosomal biogenesis, is part of a well- documented cancer specific translocation t(6;11) [41, 42]. The gene discussed is TFEB; the disease is esophageal cancer.