Studies with growth hormone replacement therapy (GHT), performed mostly in children with PWS but also in adult PWS subjects, show positive effects on height, FM, LBM, visceral adipose tissue, HDL-cholesterol, CRP, adiponectin, physical activity, cardiovascular features, cognition and quality of life without significant impairments in glucose homeostasis [30, 46–55]. This evidence concerns the gene GH1 and Prader-Willi syndrome.