A most recent study reported that TLR5 mRNA expression was increased in placenta with chorioamnionitis.(12) Moreover, the present study demonstrated that TLR5 protein expression was increased and showed a trend toward an increase, in the amnion and chorion respectively, i.e., the fetal membrane, and not affected in the decidua and villi with preterm HCA. This evidence concerns the gene TLR5 and hepatocellular adenoma.