Based on qPCR expression analysis, Hep3B, known as a well-differentiated epithelial HCC cell line31, exhibited lower ACHE/BCHE expression/activity while a highly tumorigenic mesenchymal cell-line obtained from liver cancer adenoma32, SKHep1, showed high levels of ACHE/BCHE expression/activity. Here, ACHE is linked to hepatocellular carcinoma.