Among 24 candidates, 8 proteins including Myosin light chain family members (MYLPF, MYL4 and MYL2), creatinine kinase, serotransferrin, heat shock protein A8, carbonic anhydrase 1 and Glyceraldehyde-3-phosphate dehydrogenase were significantly downregulated in tongue tumor tissues. Here, MYL4 is linked to tongue neoplasm.