Among 24 candidates, 8 proteins including Myosin light chain family members (MYLPF, MYL4 and MYL2), creatinine kinase, serotransferrin, heat shock protein A8, carbonic anhydrase 1 and Glyceraldehyde-3-phosphate dehydrogenase were significantly downregulated in tongue tumor tissues. This evidence concerns the gene TF and tongue neoplasm.