RIPK3 and gout: Neutrophil necroptosis seems also to be involved in the pathology of gout, because, in the mouse, gouty arthritis models based on the injection of MSU crystals into subcutaneous air pouches exhibit the gout-like tophus formation induced by neutrophil necrosis which can be reduced both by necrostatin-1 treatment or by silencing of the Ripk3 gene32.