LRRC8A and Insulin resistance: However, with super-imposed mild insulin resistance arising from a short course of high-fat diet (60% fat for 6 weeks), SWELL1-mediated ICl,SWELL becomes important for maintaining systemic fasting glycaemia, suggesting that SWELL1 may be primarily required to sustain β-cell insulin secretion in hyperglycemic states, as occur in the setting of T2D.