To determine if SWELL1 is also required for ICl,SWELL in pancreatic β-cells, we adenovirally transduced mouse insulinoma (MIN6) cells with either an shRNA-directed against Swell1 (Ad-U6-shswell1-mCherry; Fig. 1a) or a scrambled shRNA control (Ad-U6-shSCR-mCherry). Here, LRRC8A is linked to pancreatic insulinoma.