Thus, in view of the growing comprehension on CTLA-4 and PD-1 inhibitory checkpoints during tumor immune response, a new interest for immunotherapy of tumors has led to the development of co-inhibitory antibodies to re-engage the immune system, impeding its exhausted state and favoring the reactivation of their lytic and/or pro-apoptotic functions against tumor cells92–94. This evidence concerns the gene CTLA4 and neoplasm.