For example 5-Fluorouracil (5-FU) induces RIP1/MLKL-dependent necroptosis in caspase-3-deficient cancer cells18, whereas cisplatin (CDDP) caused RIP3-dependent necroptosis in apoptosis-resistant cancer cells through necrosome formation and autocrine TNF-α signaling19. The gene discussed is TNF; the disease is cancer.