VEGFA and neoplasm: However, in experimental mouse models, Bevacizumab (Avastin, a recombinant humanized antibody that binds VEGF isoforms) treatment resulted in a transient remodeling of the tumor vasculature by increasing the number of matured (i.e., pericyte covered) vessels, decrease permeability, reduce IFP, and increase perfusion in neuroblastoma xenografts.