Furthermore, the endothelin B receptor (ET-BR; receptor of the hypoxia-inducible factor (HIF)-1-regulated endothelin-1)) on tumor ECs is implicated in counteracting T-cell adhesion as neutralization of ET-BR increases tumor-infiltrated lymphocytes (TILs) and improves responsiveness to immunotherapy15. The gene discussed is EDNRB; the disease is neoplasm.