Although markers of Bregs might differ, a similar decrease or impairment of IL-10-producing B cells was also observed in patients with rheumatoid arthritis44,55–57, systemic lupus erythematosus (SLE)24,55,58,59, multiple sclerosis26,55, systemic sclerosis60, Myasthenia Gravis61, and other autoimmune diseases. This evidence concerns the gene IL10 and autoimmune disease.