IL10 and systemic lupus erythematosus: Although markers of Bregs might differ, a similar decrease or impairment of IL-10-producing B cells was also observed in patients with rheumatoid arthritis44,55–57, systemic lupus erythematosus (SLE)24,55,58,59, multiple sclerosis26,55, systemic sclerosis60, Myasthenia Gravis61, and other autoimmune diseases.