In addition to TNFα, death receptor (DR5) has been identified by genome-wide gene expression analyses as another key mediator of Smac mimetic-induced apoptosis, especially in those cancer cell lines including glioblastoma cells that undergo Smac mimetic-induced apoptosis largely independently of TNFα/TNFR114. This evidence concerns the gene TNFRSF10B and glioblastoma.