Innate immunity mediated by natural killer (NK) cells, polymorphonuclear leukocytes, and mast cells, as well as antigen-presenting cells (APCs), such as macrophages and dendritic cells (DCs), leads to the secretion of interferon gamma (IFN-γ) and perforin, as well as inflammatory cytokines that induce apoptosis of tumor cells. Here, IFNG is linked to neoplasm.