For example, re-expression of exogenous TrkA in NB cells guides cells to NGF-induced differentiation.274,277–279 Apoptotic cell death can be induced by TrkA inhibitors, like K252a (ref. 280), and GTx-186 (ref. 281) or by downregulating TrkA with miRNA-92a (ref. 282), however, these strategies are not yet clinically tested for NB. Here, NTRK1 is linked to neuroblastoma.