Several germline and sporadic genomic rearrangements have been detected in NB, for example, LIN28B (encoding lin 28 homolog B)14, PHOX2B (paired-like homeobox 2b)15, ALK (anaplastic lymphoma kinase)16, GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14)17, and MYCN18 (Table 1). The gene discussed is PHOX2B; the disease is neuroblastoma.