A more severe form of allergic response to Aspergillus is allergic bronchopulmonary aspergillosis (ABPA), which is associated with prolonged fungal exposure and typically occurs in individuals with a hypersensitive immune response, where airway inflammation, eosinophilia, and abundant production of Aspergillus-specific IgE are usually present [78]. The gene discussed is IGHE; the disease is allergic bronchopulmonary aspergillosis.