Natural Treg (nTreg) originate in the thymus and are present in the periphery, providing tolerance in early infection and limiting neutrophil activity, and induced Treg (iTreg) that are primed from naïve CD4+ Th cells, and these cells limit inflammation in later stages of infection, preventing fungal allergy by producing IL-10 and TGFβ [94]. This evidence concerns the gene CD4 and infection.