CD3, CD4, CD8, and CD19 lymphocyte subset counts were significantly correlated (ƿ ranged from 0.42 to 0.92, all p < 0.001), indicating severe overall T-cell and B-cell lymphopenia in the peripheral blood of these patients and inadequate cellular and humoral responses in the adaptive arm of the immune system. This evidence concerns the gene CD8A and lymphopenia.